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FLASH GENE

Symbol

CEACAM7

contributors: mct - updated : 23-09-2020

HGNC name	carcinoembryonic antigen-related cell adhesion molecule 7
HGNC id	1819

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.2      Physical location : 42.177.234 - 42.192.096
Synonym name	carcinoembryonic antigen gene family,2
Synonym symbol(s)	CGM2

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	14.97 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map

see CEA@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006890 5 splicing 2396 NP_008821 29.4 265 - 2015 26323304 NM_001291485 5 splicing 2376 NP_001278414 29.4 265 - 2015 26323304

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Homo sapiens   intestine large intestine rectum     Homo sapiens Endocrine pancreas       moderately Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Homo sapiens Epithelial secretory glandular endocrine   Homo sapiens Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal dimerization domain
	an immunoglobulin-like V-type domain
	an immunoglobulin-like C2-type domain

conjugated

GlycoP

HOMOLOGY

intraspecies

homolog to carcinoembryonic antigen

Homologene

FAMILY	immunoglobulin superfamily
	CEA subfamily

CATEGORY

adhesion , antigen , tumor suppressor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	attached to the membrane by a GPI-anchor

basic FUNCTION	CEACAM6 and CEACAM7 expression correlated with apoptosis at the table region of the normal colon
	cellular adhesion protein that is expressed on the surface of colon and rectum epithelial cells and is downregulated in colorectal cancers
	achieves cell adhesion through dimerization of the N-terminal IgV domain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

IFNG has two important effects on the expression levels of the CEA family molecules in colon epithelial cells: direct upregulation of CEACAM1 and promotion of cell differentiation resulting in increased expression of CEA and CEACAM6 and decreased expression of CEACAM7

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   associated with unfavorable prognosis in Colorectal cancer tumoral     --low   relatively decreased in rctal tumors that developed recurrence compared with nonrecurrence, significantly for stage II patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	CEACAM7, SLC4A4, GCG and CLCA1 may be prognostic markers or therapeutic targets of Colorectal cancer
	potential tumor marker to define a subset of patients who benefit most from adjuvant therapy
Therapy target

ANIMAL & CELL MODELS