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FLASH GENE
Symbol CEACAM3 contributors: mct - updated : 13-12-2016
HGNC name carcinoembryonic antigen-related cell adhesion molecule 3
HGNC id 1815
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like V-type domain
  • a cytosolic domain involved in S100A9 interaction
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to carcinoembryonic antigen
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CEA subfamily
    • CATEGORY adhesion , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • acting as a tumor antigen
  • playing an important role in the clearance of pathogens by the innate immune system
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GRB14 is the first negative regulator of CEACAM3-initiated bacterial phagocytosis and might help to focus granulocyte responses to the subcellular sites of pathogen-host cell contact
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS