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FLASH GENE
Symbol FZD9 contributors: mct - updated : 24-08-2011
HGNC name frizzled homolog 9 (Drosophila)
HGNC id 4047
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • receptor consisting of a N terminal cysteine-rich domain, seven transmembrane segments (7TM)
  • one FZD domain for ligand binding
  • a C terminal hydrophilic segment,comprising the S/T-X-X-X-W motif
    • HOMOLOGY
    interspecies homolog to Drosophila frizzled polarity gene
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope
    basic FUNCTION
  • activating Dishevelled
  • exhibiting characteristics of a WNT receptor
  • critical determinant of hippocampal development and is very likely to be a contributing factor to the neurodevelopmental and behavioral phenotype of patients with Williams syndrome
  • receptor of Wnt ligands, playing key roles in liver carcinogenesis
  • having a function in osteoblasts, a finding that may have therapeutic implications for bone loss disorders (
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    transmetting WNT signal in brain
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT2 could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    FZD9-siRNA could represent a useful therapeutic target for hepatocellular carcinoma (HCC) and hepatoblastoma (HB)
    ANIMAL & CELL MODELS
  • Fzd9(-/-) mice display low bone mass caused by impaired bone formation
  • Frizzled 9-null mice had generally normal gross anatomical hippocampal organization but showed large increases in apoptotic cell death in the developing dentate gyrus