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FLASH GENE

Symbol

FZD9

contributors: mct - updated : 24-08-2011

HGNC name	frizzled homolog 9 (Drosophila)
HGNC id	4047

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	2.34 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - FZD9 - STX1A - [ELN - LIMK1 - RFC2 ] - qter
Authors	Wang (97),Osborne (97)

regionally located

located in the WBS1 deletion

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003508 1 - 2342 - 591 - 1999 10198163

EXPRESSION

Rna function	mRNAs expressed specifically in adult spiral ganglion neurons (
Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain diencephalon hypothalamus       brain limbic system hippocampus     Homo sapiens Reproductive male system testis       Urinary kidney         Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	brain, developing neural tube
	found in the growth cones of adult spiral ganglion neurons

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	receptor consisting of a N terminal cysteine-rich domain, seven transmembrane segments (7TM)
	one FZD domain for ligand binding
	a C terminal hydrophilic segment,comprising the S/T-X-X-X-W motif

HOMOLOGY

interspecies

homolog to Drosophila frizzled polarity gene

Homologene

FAMILY

G protein coupled receptor superfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope

basic FUNCTION	activating Dishevelled
	exhibiting characteristics of a WNT receptor
	critical determinant of hippocampal development and is very likely to be a contributing factor to the neurodevelopmental and behavioral phenotype of patients with Williams syndrome
	receptor of Wnt ligands, playing key roles in liver carcinogenesis
	having a function in osteoblasts, a finding that may have therapeutic implications for bone loss disorders (

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

transmetting WNT signal in brain

a component

INTERACTION

DNA

RNA

small molecule

protein

WNT2 could act through its receptor FZD9 to regulate the CTNNB pathway in cumulus cells, recruiting CTNNB into plasma membranes and promoting the formation of adherens junctions involving CDH1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive liver FZD9-siRNA could represent a useful therapeutic target for hepatocellular carcinoma (HCC) and hepatoblastoma (HB)

ANIMAL & CELL MODELS

	Fzd9(-/-) mice display low bone mass caused by impaired bone formation
	Frizzled 9-null mice had generally normal gross anatomical hippocampal organization but showed large increases in apoptotic cell death in the developing dentate gyrus