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FLASH GENE
Symbol SUMO3 contributors: mct - updated : 27-09-2023
HGNC name SMT3 suppressor of mif two 3 homolog 1 (yeast)
HGNC id 11124
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central ubiquitin domain
  • a conserved C terminal Gly-Gly residues
    • HOMOLOGY
    interspecies ortholog to yeast S.cerevisiae SMT3 (suppressor of mutations in centromeric protein MIF2)
    intraspecies homolog to CENPC
    homolog to SUMO2 (97p100)
    Homologene
    FAMILY
  • ubiquitin family
  • SUMO subfamily
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • SUMO-2/3 localize to centromeres and condensed chromosomes
  • ARHGAP21 co-localizes with SUMO2/3 in the cytoplasm and membrane compartments
    • basic FUNCTION
  • involved in the function and/or structure of the eukaryotic kinetochore
  • ubiquitin-like protein that can be conjugated to other proteins in a manner analogous to ubiquitination
  • SUMO-2/3 conjugation and the ubiquitin-proteasome system are tightly integrated and act in a cooperative manner
  • with other SUMO proteins, binding to lysine residues of target proteins and thereby modifying their stability, activity and subcellular localization
  • with SUMO2 and SUMO1 accumulate at DNA double-strand breaks sites in mammalian cells, with SUMO1 and SUMO2/3 accrual requiring the E3 ligase enzymes PIAS4 and PIAS1
  • SUMO2 and SUMO3 can rapidly convert to be conjugated in response to a variety of cellular stresses
  • SUMO2 and SUMO3 are specific and essential negative regulators of a noncanonical mechanism of IFN induction
    • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • kinetochore
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targeting proteins
  • covalently binding and modifying RANGAP1 involved in nuclear transport
  • interacting with CENPE (CENPE was found to be modified specifically by SUMO-2/3 and to possess SUMO-2/3 polymeric chain-binding activity essential for kinetochore localization)
  • EGLN3 SUMOylation by SUMO2 or SUMO3 contributes to EGLN3-mediated repression of HIF1-dependent transcriptional activity
  • PES1 could be modified by the small ubiquitin-like modifier (SUMO) SUMO1, SUMO2 and SUMO3, and SUMOylation of PES1 was stimulated by estrogen (E2)
  • SENP2 genetically interacts with SUMO2 and SUMO3 pivotal for the development of three major trophoblast layers
  • SUMO3 modification of PIAS1 modulates AR cellular distribution and stability
  • TRIM28 binds NLRP3, promotes SUMO1, SUMO2 and SUMO3 modification of NLRP3, and thereby inhibits NLRP3 ubiquitination and proteasomal degradation
  • SUMO3 or SUMO3-modified proteins modulate likely the localization, stability, and RING ubiquitin ligase activity of TRIM55
    • cell & other
    REGULATION
    repressed by expression of SUMO3, can be down-regulated at the transcription level by cellular oxidative stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS