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FLASH GENE
Symbol RPS15 contributors: npt/mct - updated : 16-01-2023
HGNC name ribosomal protein S15
HGNC id 10388
Location 19p13.3      Physical location : 1.438.362 - 1.440.492
Synonym name
  • 40S ribosomal protein S15
  • homolog of rat insulinoma
  • insulinoma protein
    • Synonym symbol(s) MGC111130, uS19
    DNA
    TYPE functioning gene
    STRUCTURE 2.13 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 501 - 145 - 2022 35438042
    4 - 653 - 152 - 2022 35438042
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text liver at the early stage of pregnancy
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal tail of RPS15 play likely a role in mature ribosomes, namely during translation elongation, and integrity of the RPS15 C-terminal tail plays an important role during late pre-40S maturation ( , and C-terminal extension that has no homology in the bacterial counterparts
    • HOMOLOGY
    interspecies homolog to rattus rig (insulinoma gene)
    Homologene
    FAMILY
  • ribosomal protein S19P family
    • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • 40S ribosomal protein S15
  • determinant of preribosomal nuclear export in human cells (Rouquette 2005)
  • having an essential role for proliferation in all cells (Robledo 2008)
  • has an extra-ribosomal function concerned with its direct involvement in the regulation of the activity of an important tumor suppressor TP53 in the MDM2/MDMX/TP53 pathway
  • relevant role for RPS15 in the natural history of chronic lymphocytic leukemia (CLL)
  • is involved in early nucleolar ribosome biogenesis and subsequent nuclear export of pre-40S particles to the cytoplasm
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the small 40S ribosomal subunit
  • component of the decoding site of ribosomes
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • RPL37, RPS15 and RPS20 regulate the MDM2-TP53-MDM4 network
  • tRNA-derived small RNAs LeuCAG3&
    • 8242;tsRNA, induces apoptosis in rapidly dividing cells in vitro and binds at least two ribosomal protein mRNAs (for RPS28 and RPS15) to enhance their translation
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS