| basic FUNCTION
| receptor for corticotropin releasing factor |
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may be playing a central anxiolytic role at least time in mice |
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coupling with Gs alpha protein and activating adenylate cyclase |
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functioning as a local negative regulator of glucose uptake in skeletal muscle and encouraging exploration of the possibility that suppression of the UCN 2/CRHR2 pathway may provide benefits in insulin-resistant states such as type 2 diabetes |
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play a facilitatory role in the non-clathrin-, non-caveolae-mediated endocytosis and intracellular signal transduction of urocortin (Tu 2007) |
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CRHR2-positive neurons in the posterior medial amygdala are involved in the neural response to social defeat  |
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activation of CRHR2 inhibits P-currents in Purkinje neurons via G(o)alpha-dependent PLC/PKCepsilon pathway, which might contribute to its physiological functions in the cerebellum |
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its activation could inhibit MAPK8 and AKT1 phosphorylation to suppress the secretion of VEGFA in small cell lung carcinoma cells |
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novel role for UCN3 and CRHR2 related to the processing of social cues and to the establishment of social memories |
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CRHR1 and CRHR2 differentially modulate the dendritic growth of hippocampal neurons |
