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FLASH GENE

Symbol

MMP16

contributors: npt/ - updated : 04-05-2004

HGNC name	matrix metalloproteinase 16 (membrane-inserted)
HGNC id	7162

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	290.26 kb     10 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005941 10 splicing 6347 NP_005932 - 607 blood vessels Takino NM_022564 8 splicing 1800 NP_072086 - 457 ovary Takino

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine small intestine       Nervous brain         Reproductive female system ovary         male system prostate       Respiratory lung

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta, brain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	prodomain with a cysteine residue,essential for latency and involved in autocatalytic activation
	a catalytic domain with the zinc binding site (the cysteine switch)
	a hinge region
	a furin activation sequence
	one hemopexin-like domain
	a C terminal hydrophobic extension,representing a putative transmembrane segment

conjugated

HemoP , MetalloP

HOMOLOGY

interspecies

homolog to murine Mmp16

Homologene

FAMILY

peptidase M10A family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	endopeptidase degrading various components of the extracellular matrix
	activates pro_MMP2
	involved in the matrix remodeling of blood vessels
	have a role in reduced cell adhesion and spreading

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

membrane constituent

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+
	ca2+

protein

binding TIMPs in a 1:1 stoechiometry

cell & other

REGULATION

activated by

furin (intracellularly) and proteinases

inhibited by

TIMPs and TFPI2

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   with MMP2 in melanoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS