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FLASH GENE

Symbol

EIF4EBP1

contributors: mct/npt - updated : 20-10-2017

HGNC name	eukaryotic translation initiation factor 4E binding protein 1
HGNC id	3288

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   hyperphosphorylated in some cancers tumoral         phosphorylated EIF4EBP1 expression in endometrial cancer correlates with aggressive tumors and prognosis (Castellvi 2009) tumoral     --over   upregulation in eutopic endometrium may be associated with the pathogenesis of endometriosis (Laudanski 2009)

Susceptibility

Variant & Polymorphism

Candidate gene	expression of mTOR and EIF4EBP1 characterize high-grade, high-stage endometrial adenocarcinomas and might be predictive markers of a response to rapamycin (Darb-Esfahani 2009)
Marker
Therapy target
	System Type Disorder Pubmed cancer     for cancer therapy, potentially (small-molecule inhibitors that pharmacologically mimic function) cancer skin   phosphorylated EIF4EBP1 is associated with poor survival in melanoma and effective inhibition of the pathways responsible for EIF4EBP1 phosphorylation should be considered to improve the treatment outcome of metastatic melanoma patients

ANIMAL & CELL MODELS

elevated Eif4ebp1 expression observed in the retina of diabetic rodents is the result of O-GlcNAcylation of Eif4ebp1 within its PEST motif