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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

USP9X

contributors: mct - updated : 05-09-2019

HGNC name	ubiquitin specific peptidase 9, X-linked
HGNC id	12632

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRX99 , MRXS99F

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   increased expression in follicular lymphomas and diffuse large B-cell lymphomas correlates with increased MCL1 expression and poor prognosis tumoral       loss of function inactivated in over 50p100 of the pancreatic ductal adenocarcinoma (PDA) constitutional     --low   lower levels of cytosolic USP9X and deubiquitinase activity in alpha-synucleinopathies may contribute to the accumulation and aggregation SNCA in Lewy bodies constitutional       loss of function resulted in changes to the neuronal cytoskeleton constitutional germinal mutation       associated with nonsyndromic X-linked intellectual disability

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	marker prognostic in follicular lymphomas and diffuse large B-cell lymphomas
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate targeting the USP9X/PBX1 axis could be a potential therapeutic strategy for managing advanced prostate cancer cancer hemopathy   therapy target in follicular lymphomas and diffuse large B-cell lymphomas

ANIMAL & CELL MODELS