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FLASH GENE

Symbol

VIPR2

contributors: mct - updated : 13-09-2023

HGNC name	vasoactive intestinal peptide receptor 2
HGNC id	12695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer as compared to non-tumor tissue ( tumoral     --low   in esophageal squamous cell carcinoma (ESCC) tumoral     --over   excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma

Susceptibility

to chromosome rearrangements to age-related macular degeneration (AMD) to myopia

Variant & Polymorphism other	low-copy repeat (LCR) sequences in VIPR2 can mediate the formation of inversions and more complex structural rearrangements through non-allelic homologous recombination
	rs3793217 associated with AMD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS