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FLASH GENE
Symbol VIPR2 contributors: mct - updated : 13-09-2023
HGNC name vasoactive intestinal peptide receptor 2
HGNC id 12695
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM)
HOMOLOGY
Homologene
FAMILY secretin receptor superfamily, G protein coupled
CATEGORY receptor
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • presents an extranuclear localization
    • basic FUNCTION
  • responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production
  • VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
  • VIP/VIPR2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders
  • controls breast tumor growth by regulating the cAMP/PKA/ERK signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with VIP and VIPR1 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    tumoral     --low  
    in esophageal squamous cell carcinoma (ESCC)
    tumoral     --over  
    excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma
    Susceptibility
  • to chromosome rearrangements
  • to age-related macular degeneration (AMD)
  • to myopia
    • Variant & Polymorphism other
  • low-copy repeat (LCR) sequences in VIPR2 can mediate the formation of inversions and more complex structural rearrangements through non-allelic homologous recombination
  • rs3793217 associated with AMD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS