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FLASH GENE

Symbol

VIPR2

contributors: mct - updated : 13-09-2023

HGNC name	vasoactive intestinal peptide receptor 2
HGNC id	12695

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed VIPR2-2 - - 1640 - 438 - 1999 10481065 truncated isoform lacking the region in the third intracellumlar loop, the fourth extra-cellular loop and TM6-7 having a severe inability to activate adenylate-cyclase and produce cAMP NM_003382 13 - 3958 - 438 - 1999 10481065 NM_001304522 10 - 3614 NP_001291451 - 358 - 1999 10481065 NM_001308259 10 - 3788 NP_001295188 - 422 - 1999 10481065

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Nervous brain       predominantly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly Nervous central     predominantly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM)

HOMOLOGY

Homologene

FAMILY

secretin receptor superfamily, G protein coupled

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	presents an extranuclear localization

basic FUNCTION	responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production
	VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
	dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
	VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
	VIP/VIPR2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders
	controls breast tumor growth by regulating the cAMP/PKA/ERK signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction with VIP and VIPR1 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in breast cancer as compared to non-tumor tissue ( tumoral     --low   in esophageal squamous cell carcinoma (ESCC) tumoral     --over   excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma

Susceptibility

to chromosome rearrangements to age-related macular degeneration (AMD) to myopia

Variant & Polymorphism other	low-copy repeat (LCR) sequences in VIPR2 can mediate the formation of inversions and more complex structural rearrangements through non-allelic homologous recombination
	rs3793217 associated with AMD

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS