Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol VIPR2 contributors: mct - updated : 13-09-2023
HGNC name vasoactive intestinal peptide receptor 2
HGNC id 12695
Location 7q36.3      Physical location : 158.820.866 - 158.937.649
Synonym symbol(s) VPAC2, FLJ16511
DNA
TYPE functioning gene
STRUCTURE 116.78 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map cen - D7S22 - D7S98 - D7S68 - (3'- VIPR2 - 5') - D7S593 - D7S591 - D7S592 - D7S590 - D7S594 - qter
Authors MacKay (96)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 1640 - 438 - 1999 10481065
  • truncated isoform lacking the region in the third intracellumlar loop, the fourth extra-cellular loop and TM6-7
  • having a severe inability to activate adenylate-cyclase and produce cAMP
    • 13 - 3958 - 438 - 1999 10481065
    10 - 3614 - 358 - 1999 10481065
    10 - 3788 - 422 - 1999 10481065
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly
    Nervouscentral  predominantly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    		seven transmembrane segments (7TM)
    HOMOLOGY
    Homologene
    FAMILY secretin receptor superfamily, G protein coupled
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • presents an extranuclear localization
    • basic FUNCTION
  • responding to the pituitary adenylate cyclase activating polypeptide in stimulating cAMP production
  • VIPR2 and/or ADCYAPR1 receptor activation is involved in cutaneous active vasodilation in humans
  • dual role for VIPR1 and VIPR2 receptors in mediating the antiproliferative effects of VIP with VIPR2 appearing to play a more dominant role
  • VIP and its receptors (VIPR1, VIPR2) are involved in proliferation, survival, and differentiation in human breast cancer cells
  • VIP/VIPR2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders
  • controls breast tumor growth by regulating the cAMP/PKA/ERK signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction with VIP and VIPR1 (expands the pool of symmetrically dividing postnatal dentate gyrus precursors via VIPR2 receptors or directs them toward a neuronal fate via VIPR1 receptors)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer as compared to non-tumor tissue (
    tumoral     --low  
    in esophageal squamous cell carcinoma (ESCC)
    tumoral     --over  
    excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma
    Susceptibility
  • to chromosome rearrangements
  • to age-related macular degeneration (AMD)
  • to myopia
    • Variant & Polymorphism other
  • low-copy repeat (LCR) sequences in VIPR2 can mediate the formation of inversions and more complex structural rearrangements through non-allelic homologous recombination
  • rs3793217 associated with AMD
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS