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FLASH GENE
Symbol IDS contributors: mct - updated : 03-07-2009
HGNC name iduronate 2-sulfatase
HGNC id 5389
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • sulfatase domain
    • HOMOLOGY
    interspecies homolog to murine Ids
    Homologene
    FAMILY
  • sulfatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • iduronate 2-sulfatase, acting on dermatan sulfate, heparan sulfate
  • catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
  • lysosomal exo-sulphatase involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS2
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS