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FLASH GENE
Symbol IDS contributors: mct - updated : 03-07-2009
HGNC name iduronate 2-sulfatase
HGNC id 5389
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 5876 61.8 550 - 2007 17655837
8 - 1437 - 343 - 2007 17655837
- - 5832 - 460 - -
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectivebone   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
 digestive
Blood/Hematopoieticleukocyte
Digestivehepatocyte
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • sulfatase domain
    • HOMOLOGY
    interspecies homolog to murine Ids
    Homologene
    FAMILY
  • sulfatase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • iduronate 2-sulfatase, acting on dermatan sulfate, heparan sulfate
  • catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
  • lysosomal exo-sulphatase involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) MPS2
    related resource Mucopolysaccharidosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS