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FLASH GENE

Symbol

IDS

contributors: mct - updated : 03-07-2009

HGNC name	iduronate 2-sulfatase
HGNC id	5389

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	26.57 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence

cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	cen - DXS369 - DXS8028 - DXS1200 - DXS181 - DXS297 - DXS998 - DXS532 - DXS548 - FRAXA - DXS308 - DXS465 - DXS293 - DXS533 - DXS1215 - DXS8091 - FRAXE /DXS296 - (DXS295 - DXS185 ),(DXS1193 - DXS1123 - IDS - DXS1113 ) - IDSP1 - DXS466 - DXS29 - DXS49 - DXS304 - DXS305 - DXS52 - qter
Text	see FRAXA , FRAXE , IDSCR

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000202 9 - 5876 NP_000193 61.8 550 - 2007 17655837 NM_006123 8 - 1437 NP_006114 - 343 - 2007 17655837 NM_001166550 - - 5832 NP_001160022 - 460 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Respiratory lung         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Connective bone       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol   digestive Blood/Hematopoietic leukocyte Digestive hepatocyte Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

sulfatase domain

HOMOLOGY

interspecies

homolog to murine Ids

Homologene

FAMILY

sulfatase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	iduronate 2-sulfatase, acting on dermatan sulfate, heparan sulfate
	catalyzing the first step of degradation of glucosaminoglycans (mucopolysaccharides)
	lysosomal exo-sulphatase involved in the degradation of the glycosaminoglycans heparan sulphate and dermatan sulphate

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

targeted to the lysosome by M6P receptor mediated pathway

ASSOCIATED DISORDERS

corresponding disease(s)

MPS2

related resource

Mucopolysaccharidosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS