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FLASH GENE
Symbol GLRA2 contributors: - updated : 19-12-2005
HGNC name glycine receptor, alpha 2
HGNC id 4327
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ligand gated ion (Cl) channel
  • four transmembrane segments
    • mono polymer pentamer
    HOMOLOGY
    interspecies homolog to murine Glra2
    Homologene
    FAMILY ligand-gated ionic channel family
    CATEGORY receptor membrane ligand ion channel , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • increasing the chloride conductance and thus producing hyperpolarization
  • signaling through GLRA2 plays a role in photoreceptor development in the retina, mediated by taurine
  • playing a role during the early stages of CNS development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS