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FLASH GENE
Symbol GK contributors: mct - updated : 07-04-2007
HGNC name glycerol kinase
HGNC id 4289
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Gyk
homolog to rattus Gyk
Homologene
FAMILY FGGY kinase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,cytosolic
text bound to mitochondria in sperm and fetal tissues, but found in cytoplasm in adult tissues
basic FUNCTION
  • catalyzing the phosphorylation of glycerol to glycerol-3-phosphate
  • key enzyme in the regulation of glycerol uptake and metabolism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GKD
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    glycerol kinase-deficient mice, mutant male mice appeared normal at birth, but exhibited postnatal growth retardation, altered fat metabolism with profound hyperglycerolemia and elevated free fatty acids, autonomous glucocorticoid synthesis, and death by 3 to 4 days of age whereas heterozygous females were healthy and biochemically normal