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FLASH GENE
Symbol OPN1MW contributors: mct/ - updated : 21-12-2022
HGNC name opsin 1 (cone pigments), medium-wave-sensitive
HGNC id 4206
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen    
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsensoryvisual  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualcone photoreceptor
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text eye
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • Opsin subfamily
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • medium wave photon absorption with a maximum at 530 nm (in the green)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    PATHWAY
    metabolism
    signaling sensory transduction/vision
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by OPN1MW (Liu 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) CBD , CBBM1 , CORDX5
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mef2c knock-down in murine 661W cells reduced the expression of Arr3 and Opn1mw but increased transcript levels of Mapk15 and Pde6h