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FLASH GENE

Symbol

OPN1MW

contributors: mct/ - updated : 21-12-2022

HGNC name	opsin 1 (cone pigments), medium-wave-sensitive
HGNC id	4206

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000513 6 - 1998 NP_000504 40.6 364 - 2002 12051694

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen         Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial sensory visual

cells

System Cell Pubmed Species Stage Rna symbol Visual cone photoreceptor

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY	G-protein coupled receptor 1 family
	Opsin subfamily

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

medium wave photon absorption with a maximum at 530 nm (in the green)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

sensory transduction/vision

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

OPN1MW (Liu 2007)

ASSOCIATED DISORDERS

corresponding disease(s)

CBD , CBBM1 , CORDX5

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Mef2c knock-down in murine 661W cells reduced the expression of Arr3 and Opn1mw but increased transcript levels of Mapk15 and Pde6h