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FLASH GENE

Symbol

GABRA3

contributors: mct - updated : 17-10-2014

HGNC name	gamma-aminobutyric acid (GABA) A receptor, alpha 3
HGNC id	4077

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a ligand binding site in the N terminal region
	four transmembrane segments
	one of which forming the wall of the channel
	a large intracellular loop

HOMOLOGY

Homologene

FAMILY

ligand-gated ionic channel family

CATEGORY

receptor membrane ligand ion channel , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION

mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of a pentameric receptor mediating inhibitory neurotransmission

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional         inducing a hyperdopaminergic phenotype, with a severe deficit in sensorimotor gating, a common feature among psychiatric conditions, including schizophrenia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	target for novel antipsychotic drugs

ANIMAL & CELL MODELS