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FLASH GENE
Symbol TAF1 contributors: mct/npt - updated : 13-01-2016
HGNC name TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
HGNC id 11535
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal kinase activity
  • TATA box binding protein
  • one HMG box domain
  • two bromodomains (Bromo1, and Bromo2), each of which consists of a bundle of four alpha helices that form a hydrophobic pocket that can recognize acetylated lysines found on the N-terminal tails of histones
  • a WH domain having intrinsic DNA-binding activity, which depends on characteristic residues that are commonly used by WH fold proteins for interacting with DNA
    • HOMOLOGY
    interspecies homolog to murine Taf1
    Homologene
    FAMILY
  • TAF1 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing an essential role in the contrôle of the cell cycle (progression of the G1 phase)
  • phosphorylating histone 2B for transcriptional activation and promoting cell cycle progression and development
  • playing a specific role in transcription activation from a TATA-less, DPE containing promoter that is not observed with a TATA-containing, DPE-less promoter
  • autophosphorylating and transphosphorylating TFIIF both modulating a pression of different subsets of genes
  • stimulates the ubiquitylation and degradation of TP53 in a manner that is dependent upon MDM2 and requires its acidic domain (Allende-Vega 2007)
  • multifunctional protein that has been reported to possess activities related to DNA promoter binding, histone acetylation, and protein phosphorylation
  • TAF1 regulates PAX3 protein levels through its ability to mediate monoubiquitination, revealing a critical interaction between two proteins that are involved in distinct aspects of myogenic differentiation
  • TAF1 and CIITA both possess intrinsic acetyltransferase (AT) activity that is required for transcription initiation
  • TAF1 and TAF7, two subunits of TFIID, are integral to the regulation of eukaryotic transcription initiation and play key roles in preinitiation complex (PIC) assembly
  • novel roles for the TAF1-TAF7 complex in regulation of PIC assembly via reading epigenetic histone marks
  • critical promoter-binding function of TAF1 in transcription regulation
    • CELLULAR PROCESS cell cycle
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the transcription initiation complex TFIID
  • part of TAF1/DYT3, a complex transcript system that is composed of at least 43 exons (Herzfeld 2007)
    • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • TATA box binding (TBP)
  • interacting with JUN, for transcriptional activation
  • interacting with CK2 (recruitment of CK2 by TAF1 may play a contributory role in the maintenance of MDM2 phosphorylation and function) (Allende-Vega 2008)
  • because TAF1 is a coactivator of AR that binds and enhances AR transcriptional activity, its overexpression could be part of a compensatory mechanism adapted by cancer cells to overcome reduced levels of circulating androgens
  • TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription
  • TAF1 binds directly to PAX3 and overexpression of TAF1 increases the level of monoubiquitinated PAX3 and its degradation by the proteasome
  • TAF1 is able to phosphorylate TP53 on Thr55, which leads to dissociation of TP53 from the CDKN1A promoter
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DYT3 , MRXS33
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    may serve as novel targets for the treatment of liver fibrosis
    ANIMAL & CELL MODELS
  • in the rat brain, N-taf1 protein appears as a nuclear protein within subsets of neurons in multiple brain regions