Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDX4 contributors: mct - updated : 16-06-2016
HGNC name caudal type homeobox transcription factor 4
HGNC id 1808
Location Xq13.2      Physical location : 72.667.089 - 72.674.420
Synonym name
  • Drosophila caudal family member 4, murine Cdx4 homolog, homeo domain encoding gene
    • DNA
    TYPE functioning gene
    STRUCTURE 7.33 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site
    text structure
  • HOXA10-binding cis element in the CDX4 promoter that activated transcription
    • MAPPING cloned Y linked   status provisional
    Map see XIC
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 855 - 284 - 2012 23038246
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an helix-turn-helix homeobox DNA binding domain
    • HOMOLOGY
    interspecies homolog to rattus Cdx4 (83.8 pc)
    homolog to murine Cdx4 (83 pc)
    Homologene
    FAMILY
  • caudal homeobox family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • is required in the endoderm to localize the pancreas and limit beta-cell number
  • is dispensable for the establishment and maintenance of normal hematopoiesis in adult
  • CDX4 participates likely in MLL-AF9-mediated leukemogenesis supporting a role for CDX factors in the pathogenesis of myeloid leukemia
  • while both canonical WNT and CDX2 can regulate the activity of the CDX4 promoter, they appear to operate through distinct mechanisms
  • is a homeodomain transcription factor that was also implicated in myeloid leukemogenesis
  • auto- and cross-regulation of CDX4 and SALL4 establish a stable molecular circuit in the mesoderm that facilitates the activation of the blood-specific program as development proceeds
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • CDX4 influenced transcription of HOXA10 target genes in a HOXA10-dependent manner
  • FGF2 and CDX4 are direct target genes of HOXA10 and HOXA10 is a CDX4 target gene
  • CTNNB1 activates the HOXA10 and CDX4 genes in myeloid progenitor cells
  • CDX4 activates transcription of the HOXA9 and HOXA10 genes, and HOXA10 activates CDX4 transcription
  • interactions between CYP26A1 and CDX4 modulate RA levels along the anterior-posterior (AP) axis to segregate the posterior neural plate into the hindbrain and spinal cord territories
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS