basic FUNCTION
| involved in mesenchymal-mesenchymal signaling for the development of inner ear |
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transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain |
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has a critical role in the neuronal differentiation of mesencephalic neural stem cells and the maturation of newborn neurons |
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POU-domain transcription factor required for inner ear development |
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implicated in the regeneration and repair of denervated striatum |
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prominent role in inner ear development |
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POU3F4 in the otic mesenchyme establishes an EPH/ephrin-mediated fasciculation signal that promotes inner radial bundle formation |
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in the ear, POU3F4 is essential for mesenchymal remodeling of the bony labyrinth |
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POU3F4 and TH synergistically promote the differentiation of neural stem cells into dopaminergic neurons |
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POU3F4 likely substantially contributes to cochlear gap junction properties to maintain the proper endocochlear potential (EP) in cochleae, similar to connexin-related deafness |