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FLASH GENE
Symbol CETN1 contributors: mct - updated : 11-07-2012
HGNC name centrin, EF-hand protein, 1
HGNC id 1866
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative EF-hand calcium binding domain
    • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • centrosome during interphase, redistributed to spindle poles at the beginning of mitosis
  • associated with centrosome-related structures
  • co-localizes with GRK5, TUBG1, and pericentrin in centrosomes
    • basic FUNCTION
  • plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of interphase cells and of mitotic spindle poles at mitosis
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cooperate with CP110 and calmodulin to regulate progression through cytokinesis
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • interacting with SUMO-2/3 (possible role of calcium in modulating the CETN1-SUMO-2/3 interaction)
    • cell & other
    REGULATION
    Other phosphorylated during the cell cycle and play a role in centriole separation preceding centrosome duplication
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS