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FLASH GENE
Symbol CETN1 contributors: mct - updated : 11-07-2012
HGNC name centrin, EF-hand protein, 1
HGNC id 1866
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemplacenta   
 male systemtestis   
Visualeyeretina    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Reproductiveciliated cell Homo sapiens
Reproductivegerm cell Homo sapiens
Reproductivesperm cell Homo sapiens
Visualcone photoreceptor Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative EF-hand calcium binding domain
    • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • centrosome during interphase, redistributed to spindle poles at the beginning of mitosis
  • associated with centrosome-related structures
  • co-localizes with GRK5, TUBG1, and pericentrin in centrosomes
    • basic FUNCTION
  • plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing
    • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of interphase cells and of mitotic spindle poles at mitosis
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • cooperate with CP110 and calmodulin to regulate progression through cytokinesis
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • interacting with SUMO-2/3 (possible role of calcium in modulating the CETN1-SUMO-2/3 interaction)
    • cell & other
    REGULATION
    Other phosphorylated during the cell cycle and play a role in centriole separation preceding centrosome duplication
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS