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FLASH GENE

Symbol

BMX

contributors: - updated : 23-12-2005

HGNC name	BMX non-receptor tyrosine kinase
HGNC id	1079

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	49.00 kb     19 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system ovary     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial

cells

System Cell Pubmed Species Stage Rna symbol   epithelial cell Cardiovascular endothelial cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	SH2, SH3 domains
	a pleckstrin homology (PH)
	a catalytic domain
	a BTK-type zinc finger

HOMOLOGY

Homologene

FAMILY	SRC family
	k1 Tec subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may play a role in the growth and differentiation of hematopoietic cells
	may be involved in signal transduction in endocardial and arterial endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text

mesoderm

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	binds 1 zinc ion per subunit

protein

cell & other

REGULATION

activated by

IL6 through phosphatidylinositol 3-kinase pathway,in a prostate cancer cell line

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS