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FLASH GENE
Symbol BMX contributors: - updated : 23-12-2005
HGNC name BMX non-receptor tyrosine kinase
HGNC id 1079
Location Xp22.2      Physical location : 15.518.899 - 15.574.651
Synonym name bone marrow tyrosine kinase, X-linked
Synonym symbol(s) BMK, ETK, PSCTK2, PSCTK3
EC.number 2.7.1.112
DNA
TYPE functioning gene
STRUCTURE 49.00 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary  highly
Skin/Tegumentskin   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelial    
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • SH2, SH3 domains
  • a pleckstrin homology (PH)
  • a catalytic domain
  • a BTK-type zinc finger
    • HOMOLOGY
    Homologene
    FAMILY SRC family
    k1 Tec subfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may play a role in the growth and differentiation of hematopoietic cells
  • may be involved in signal transduction in endocardial and arterial endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text mesoderm
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    binds 1 zinc ion per subunit
    protein
    cell & other
    REGULATION
    activated by IL6 through phosphatidylinositol 3-kinase pathway,in a prostate cancer cell line
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS