SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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| intracellular,nuclear envelope,int
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text
| membrane protein type 2, inner nuclear membrane |
basic FUNCTION
| involved in nuclear lamina organization and in the stability and function of rigorously moving nuclei in tissues such as skeletal muscle, heart, joints |
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regulating gene expression in heart and muscle by interacting with specific transcription factors or DNA sequences |
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type II inner nuclear membrane (INM) protein |
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regulate the flux of beta-catenin, an important transcription coactivator, into the nucleus |
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can influence signaling pathways by restricting access of transcription coactivators to the nucleus |
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having functions in cell polarization  |
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nuclear-membrane protein with roles in nuclear architecture, gene regulation and signaling  |
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having roles as a downstream effector and signal integrator for tyrosine kinase signaling pathway(s) at the nuclear envelope  |