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FLASH GENE
Symbol SLC16A2 contributors: mct - updated : 15-09-2021
HGNC name solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
HGNC id 10923
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve hydrophobic transmembrane spanning segments
  • a large cytoplasmic loop between TM6 and TM7 and
  • a N terminal PEST domain
    • HOMOLOGY
    interspecies homolog to murine Slc16a2
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating movement of lactate and pyruvate across membranes
  • involved in the transport of triiodothyronine into neurons, very active and specific thyroid hormone transporter
  • with SLC16A10, facilitate iodothyronine uptake as well as efflux
  • may play an important role in the transport of thyroid hormone in the brain, which is essential for the crucial action of the hormone during brain development
  • may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism
  • hypoxia stimulates lactate release and modulates monocarboxylate transporter (SLC16A1, SLC16A2, and SLC16A4) expression in human adipocytes
  • is a specific and very active TH transporter
  • essential physiological requirement for SLC16A2 in chondrocytes, and likely role for additional transporters in other skeletal cells during adult bone maintenance
  • SLC16A2-dependent TH uptake in neural progenitors, revealing the importance of local TH action in early development
  • potential role of SLC16A2 in TH transport for human oligodendrocytes (OL) development
  • unique gate-keeper function of SLC16A2 and SLCO1C1 in satellite cells (SCs) activation, underscoring the importance of a finely tuned TH signaling during myogenesis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transporter
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • proton linked
    • protein
  • PTTG1IP binds and alters the subcellular localization of SLC16A2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCT8D , AHDS , DUPXQ13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    miscelleaneousthyroid 
    DITPA, (an SLC16A2-independent TH analog) is a promising treatment for developmentally-regulated myelination in AHDS
    ANIMAL & CELL MODELS
  • Mct8 knockout (ko) mice do not exhibit overt neurological symptoms but fully replicate the unusual serum TH profile with highly increased serum T3 in the presence of low serum T4