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FLASH GENE

Symbol

SLC16A2

contributors: mct - updated : 15-09-2021

HGNC name	solute carrier family 16, member 2 (monocarboxylic acid transporter 8)
HGNC id	10923

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly Homo sapiens Endocrine neuroendocrine pituitary     highly Homo sapiens   thyroid       highly Homo sapiens Nervous brain       highly Homo sapiens   brain limbic system hippocampus   highly Homo sapiens   brain forebrain cerebral cortex     Homo sapiens Urinary kidney       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve hydrophobic transmembrane spanning segments
	a large cytoplasmic loop between TM6 and TM7 and
	a N terminal PEST domain

HOMOLOGY

interspecies

homolog to murine Slc16a2

Homologene

FAMILY	major facilitator superfamily
	monocarboxylate porter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	mediating movement of lactate and pyruvate across membranes
	involved in the transport of triiodothyronine into neurons, very active and specific thyroid hormone transporter
	with SLC16A10, facilitate iodothyronine uptake as well as efflux
	may play an important role in the transport of thyroid hormone in the brain, which is essential for the crucial action of the hormone during brain development
	may be important to modulate thyroid hormone effects on osteoblast differentiation and on bone development and metabolism
	hypoxia stimulates lactate release and modulates monocarboxylate transporter (SLC16A1, SLC16A2, and SLC16A4) expression in human adipocytes
	is a specific and very active TH transporter
	essential physiological requirement for SLC16A2 in chondrocytes, and likely role for additional transporters in other skeletal cells during adult bone maintenance
	SLC16A2-dependent TH uptake in neural progenitors, revealing the importance of local TH action in early development
	potential role of SLC16A2 in TH transport for human oligodendrocytes (OL) development
	unique gate-keeper function of SLC16A2 and SLCO1C1 in satellite cells (SCs) activation, underscoring the importance of a finely tuned TH signaling during myogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	monocarboxylate transporter

PATHWAY

metabolism

monocarbon

signaling

a component

INTERACTION

DNA

RNA

small molecule	other,
	proton linked

protein

PTTG1IP binds and alters the subcellular localization of SLC16A2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

MCT8D , AHDS , DUPXQ13

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed miscelleaneous thyroid   DITPA, (an SLC16A2-independent TH analog) is a promising treatment for developmentally-regulated myelination in AHDS

ANIMAL & CELL MODELS

Mct8 knockout (ko) mice do not exhibit overt neurological symptoms but fully replicate the unusual serum TH profile with highly increased serum T3 in the presence of low serum T4