SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
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| intracellular,nucleus,nucleoplasm,nuclear bodies,PML
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| intracellular,nucleus,chromatin/chromosome,euchromosome
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| intracellular,nucleus,chromatin/chromosome,heterochromosome
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| intracellular,nucleus,chromatin/chromosome,telomere
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| intracellular,nucleus,chromatin/chromosome,centromere
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| text
| associated with pericentromeric heterochromatin during interphase and mitosis |
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associated with condensed chromatin at the onset of mitosis |
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located at G-rich tandem repeats (TRs) in telomeres and euchromatin where it may recognize unusual DNA structures |
| basic FUNCTION
| chromatin-remodeling protein, regulating gene expression via an effect on chromatin structure and/or function, at interphase and chromosomal segregation at mitosis |
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helicase involved in DNA recombination and repair and transcription regulation, down-regulator of the alpha-globin locus, playing a role in the regulation of globin gene expression |
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binding to the short arms of acrocentric chromosomes where the arrays of ribosomal DNA are located |
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involved in DNA methylation, in brain development and facial morphogenesis |
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may play an important role in transcription regulation, and involved in chromatin remodelling |
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critical mediator of cell survival during early neuronal differentiation during and corticogenesis |
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plays an important role in the recombinational repair of double-strand DNA (dsDNA) breaks |
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play important roles during homologous recombination |
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stimulates MUS81–EME1 endonuclease activity on various holliday junction-like intermediates (may cooperate in the processing of Holliday junction-like intermediates during homologous recombination or DNA repair) |
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switch/sucrose nonfermenting-type ATPase localized at pericentromeric heterochromatin  |
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contributes to chromosome dynamics during mitosis and provide a possible cellular explanation for reduced cortical size and abnormal brain development associated with ATRX deficiency |
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transcriptional regulator, playing a novel function, working in conjunction with H3F3B, H3F3A and CBX5, as a key regulator of embryonic stem-cell telomere chromatin |
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with DAXX are required for H3F3A deposition onto pericentric DNA repeats outside the S phase, and the DAXX/ATRX complex uses H3F3A to modulate the transcription from these repeats |
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may be involved in recruitment of the complex DAXX/ATRX to telomeres |
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essential for the maintenance of chromosome stability during female meiosis, and required to recruit the transcriptional regulator DAXX to pericentric heterochromatin at prophase I of meiosis |
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chromatin-remodeling factor known to regulate DNA methylation at repetitive sequences of the human genome |
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required for heterochromatin formation and maintenance of chromosome stability during meiosis |
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required for centromere stability and the epigenetic control of heterochromatin function during meiosis and the transition to the first mitosis |
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plays a critical role in the functional differentiation of chromatin structure during oogenesis and underscore the importance of chromatin remodeling proteins in the control of chromosome segregation during meiosis |
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essential epigenetic component of pericentric heterochromatin for the repression of centromere mitotic rearrangements, DNA breaks and chromosome missegregation and hence as an important guardian of centromere integrity and function |
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role of ATRX may be to recognize unusual forms of DNA and facilitate their resolution in several contexts |
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required for the timely accumulation of the homologous recombination proteins RAD51 and BRCA2 at double-strand breaks |
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important homologous recombination protein |
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promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma |
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chromatin remodeler that, together with its chaperone DAXX, deposits the histone variant H3.3 in pericentromeric and telomeric regions |
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ATRX facilitates likely the chromatin reconstitution required for extended DNA repair synthesis and sister chromatid exchange during homologous recombination (HR) |
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MECP2 and ATRX are reciprocally dependent both for their expression and targeting to chromocenters |
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is likely required in excitatory neurons of the forebrain to achieve normal hippocampal long-term potentiation (LTP) and paired-pulse facilitation (PPF) at the CA1 apical and basal dendritic synapses, respectively |
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ATRX affects telomeric DSB repair by promoting cohesion of sister telomeres and that loss of ATRX in alternative lengthening of telomeres (ALT) cells results in diminished telomere cohesion |
