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FLASH GENE
Symbol PIGA contributors: mct - updated : 25-02-2016
HGNC name phosphatidylinositol glycan anchor biosynthesis, class A
HGNC id 8957
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythrocyte
Blood/Hematopoieticgranulocyte
Lymhoid/Immunelymphocyte
cell lineage hematopoietic stem cell
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a glycosyltransferase motif
  • a C terminal transmembrane segment
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Piga (87.8pc)
    homolog to rattus Piga (88.6pc)
    Homologene
    FAMILY
  • glycosyltransferase 1 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • putatively involved in apoptosis regulation
  • anchoring proteins to the cell surface
  • required for the synthesis of N acetyl-glucosaminyl-phosphatidyl inositol,the first step in the biosynthesis pathway of GPI
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forming a complex with PIGH in the endoplasmic membrane reticulum with GPI-GlcNac transferase activity
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PIGY
  • associating with PIGC, PIGH, PIGP, PIGQ and DPM2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PNH , MCAHS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS