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FLASH GENE
Symbol MSN contributors: mct - updated : 13-09-2017
HGNC name moesin
HGNC id 7373
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal FERM (EPB41,ezrin,radixin,moesin) domain
  • cysteine-rich, basic charged globular module
  • a C-terminal actin-binding domain
    • HOMOLOGY
    Homologene
    FAMILY
  • ezrin/moesin/radixin-like moesin (ERM) family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localizes to the centrosomes and mitotic spindle during mitosis
  • in a small fraction of cells and at a low level, MSN can be detected in interphase nuclei in regions complementary to the chromatin, and its level rapidly increases during prophase and it co-localizes with the actin network surrounding the mitotic spindles throughout mitosis (pMID: 19595131)
    • basic FUNCTION
  • filopodial protein involved in cell recognition
  • cell movement and morphological changes
  • membrane-organizing extension spike protein
  • developmentally regulated and abundantly expressed in germinal matrix and/or migrating cells during cerebral cortical development
  • clustering in an endothelial actin rich docking structure with ICAM1, VCAM1, EZR
  • importance of the MSN-induced increase in cortical rigidity for spindle morphogenesis and orderly chromosome segregation
  • spatiotemporal control of MSN activation at the mitotic cortex provides localized cues to coordinate cortical contractility and microtubule interactions during cell division
  • overactivation of MSN at the polar cortex impairs cell elongation and thus cytokinesis
  • changes in the phosphorylation levels of NF2 and MSN lead likely to changes in epithelial organization
  • ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton.
  • its upregulation influences extra-centrosome behavior and robust bipolar spindle formation
    • cyte Leukocyte transendothelial migration (TEM)
  • is involved in nuclear mRNA export
  • cytoskeletal adaptor protein that plays an important role in modification of the actin cytoskeleton
  • critical role for MSN in both neuronal morphogenesis and long-term memory formation
  • supportive role of EZR, RDX, MSN in cortical activities during cytokinesis
  • EZR and MSN play mutually exclusive roles in modulating SELL signalling and shedding to control protrusion dynamics and polarity during monocyte transendothelial migration (TEM)
  • ERM proteins, EZR, radixin and moesin, assist in the formation and maintenance of specialized plasma membrane structures and membrane vesicle structures
    • CELLULAR PROCESS cell organization/biogenesis
    cell communication
    PHYSIOLOGICAL PROCESS
    text downstream effector of trafficking PRKC-integrin complex involved in the control of cell motility
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • binds to and stabilizes microtubules at the cell cortex
    • protein
  • F-actin binding
  • interacting with the cytoplasmic region of ICAM3 and redistributed to the uropod of T lymphocytes during cell polarization
  • P2RX7 stimulation triggers the phosphorylation of EZR/RDX/MSN, which translocate to the plasma membrane where they associate with P2RX7
  • RDX, EZR, MSN exert a redundant control on PDGFA-induced vascular smooth muscle cells (VSMC) migration by regulating focal adhesion turn-over and cell adhesion to substrate
  • inhibition of cell adhesion by phosphorylated EZR/RDX/MSN
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) IMD50
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioblastoma cells correlated with increases in cell proliferation, invasion and migration, suggesting moesin role in glioblastoma progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS