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FLASH GENE

Symbol

ZXDA

contributors: mct/npt - updated : 30-06-2008

HGNC name	zinc finger, X-linked, duplicated A
HGNC id	13198

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	2.00 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

located within approximately 400 kb of ZXDB

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 1 - 2886 84.8 799 - Al-Kandari (2007)

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Reproductive female system placenta       Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	C2H2 type-zinc finger domain
	a domain organization similar to ZXDC, containing ten zinc fingers
	a transcriptional activation domain

HOMOLOGY

interspecies

homolog to C.elegans ZK1248.3

Homologene

FAMILY

zinc finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

with ZXDC form an important regulatory complex for MHC II gene transcription (AlKandari 2007)

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein

interacting wirh ZXDC

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS