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FLASH GENE
Symbol ZNF81 contributors: mct - updated : 05-10-2017
HGNC name zinc finger protein 81 (HFZ20)
HGNC id 13156
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve zinc finger motifs, C2H2 type, Krüppel-like at the C terminus
  • a Kruppel-associated box (KRAB) domain
    • conjugated MetalloP
    HOMOLOGY
    intraspecies homolog to ZNF41
    Homologene
    FAMILY zinc finger protein family, C2H2 type, Krüppel-like
    CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • is thought to mediate gene silencing through the interaction with both heterochromatin protein HP1 and histon modifying proteins (histon deacetylases and methyltransferases)
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
    Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MRX45
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS