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FLASH GENE
Symbol IL2RG contributors: mct/ - updated : 10-04-2006
HGNC name interleukin 2 receptor, gamma
HGNC id 6010
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Lymphoid/Immunelymph node   moderately
 spleen   moderately
 thymus   highly
 tonsils   highly
cell lineage in lymphoid and myeloid cell lineages predominantly
cell lines
fluid/secretion blood predominantly
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 22 aa signal peptide
  • a fibronectin type III domain containing a WSXWS motif
  • a box 1 motif
    • conjugated GlycoP
    isoforms Precursor a 347 mature peptide of 40 kda
    HOMOLOGY
    interspecies ortholog to rattus Il2rg
    ortholog to murine Il2rg
    Homologene
    FAMILY
  • hematopoietic receptor family
  • type I cytokine receptor family
  • type 5 subfamily
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type I transmembrane protein
  • external side of plasma membrane
    • basic FUNCTION
  • interleukin 2, high affinity receptor gamma chain
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • functional component of IL2R, IL4R, IL7R, IL9R, IL15R, IL21R and IL13R (see SCIDX1)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SCIDX1
    related resource X-Linked Severe Combined Immunodeficiency SCID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS