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FLASH GENE

Symbol

IL2RG

contributors: mct/ - updated : 10-04-2006

HGNC name	interleukin 2 receptor, gamma
HGNC id	6010

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000206 8 - 1560 NP_000197 - 369 - -

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Lymphoid/Immune lymph node       moderately   spleen       moderately   thymus       highly   tonsils       highly

cell lineage	in lymphoid and myeloid cell lineages predominantly
cell lines
fluid/secretion	blood predominantly

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a 22 aa signal peptide
	a fibronectin type III domain containing a WSXWS motif
	a box 1 motif

conjugated

GlycoP

isoforms

Precursor

a 347 mature peptide of 40 kda

HOMOLOGY

interspecies	ortholog to rattus Il2rg
	ortholog to murine Il2rg

Homologene

FAMILY	hematopoietic receptor family
	type I cytokine receptor family
	type 5 subfamily

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	single-pass type I transmembrane protein
	external side of plasma membrane

basic FUNCTION

interleukin 2, high affinity receptor gamma chain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

PATHWAY

metabolism

signaling

signal transduction

a component

functional component of IL2R, IL4R, IL7R, IL9R, IL15R, IL21R and IL13R (see SCIDX1)

INTERACTION

DNA

RNA

small molecule

protein

IL2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

SCIDX1

related resource

X-Linked Severe Combined Immunodeficiency SCID

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS