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FLASH GENE
Symbol HTR2C contributors: mct - updated : 18-08-2010
HGNC name 5-hydroxytryptamine (serotonin) receptor 2C
HGNC id 5295
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • activating the phosphatidylinositol cycle
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger
    • system
  • HTR2B, HTR2C receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity and increased BMI
  • to metabolic syndrome in patients with schizophrenia
    • Variant & Polymorphism SNP
  • increasing the risk of obesity
  • HTR2C:c.1-142948(GT)n associated with an increased risk of the metabolic syndrome in patients with schizophrenia (Mulder 2007)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse model lacking MBII-52 snoRNAs shows differences in pre-mRNA processing of the serotonin receptor (Kishore 2010)