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FLASH GENE
Symbol HTR2C contributors: mct - updated : 18-08-2010
HGNC name 5-hydroxytryptamine (serotonin) receptor 2C
HGNC id 5295
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainbasal nucleicaudate nucleus  
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text stem cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • conjugated FlavoP
    HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • activating the phosphatidylinositol cycle
  • mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger
    • system
  • HTR2B, HTR2C receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to obesity and increased BMI
  • to metabolic syndrome in patients with schizophrenia
    • Variant & Polymorphism SNP
  • increasing the risk of obesity
  • HTR2C:c.1-142948(GT)n associated with an increased risk of the metabolic syndrome in patients with schizophrenia (Mulder 2007)
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mouse model lacking MBII-52 snoRNAs shows differences in pre-mRNA processing of the serotonin receptor (Kishore 2010)