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FLASH GENE

Symbol

HTR2C

contributors: mct - updated : 18-08-2010

HGNC name	5-hydroxytryptamine (serotonin) receptor 2C
HGNC id	5295

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000868 6 - 4774 NP_000859 51.8 458 - McGrew (2004)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain basal nuclei caudate nucleus     Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	stem cells

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

conjugated

FlavoP

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	activating the phosphatidylinositol cycle
	mediating its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger
	system
	HTR2B, HTR2C receptors on motoneurons become constitutively active after injury and ultimately contribute to recovery of motoneuron function and emergence of spasms

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

HTR2A, HTR2B, HTR2C are implicated as being critical for induction of PTHLH and RUNX2

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to obesity and increased BMI to metabolic syndrome in patients with schizophrenia

Variant & Polymorphism SNP	increasing the risk of obesity
	HTR2C:c.1-142948(GT)n associated with an increased risk of the metabolic syndrome in patients with schizophrenia (Mulder 2007)

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

mouse model lacking MBII-52 snoRNAs shows differences in pre-mRNA processing of the serotonin receptor (Kishore 2010)