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FLASH GENE
Symbol SAT1 contributors: mct - updated : 16-03-2022
HGNC name spermidine/spermine N1-acetyltransferase 1
HGNC id 10540
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , tetramer
HOMOLOGY
interspecies homolog to rattus Sat1 (96.5 pc)
homolog to murine Sat1 (96.5 pc)
Homologene
FAMILY
  • acetyltransferase family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text colocalized with SLC3A2
    basic FUNCTION
  • involved in the regulation of polyamine transport out of cells
  • catalyzing the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine
  • acting as an acyltransferase
  • may facilitate excretion of acetylated polyamines
  • functioning as a cardioprotectant under ATP-depleted conditions
  • enzyme involved in polyamine catabolism
  • promotes acetylation of histone H3, suggesting a new role of SAT1 in chromatin remodeling and regulation of gene expression
  • SAT1-mediated polyamine catabolism regulates beige adipocyte biogenesis
  • is a novel regulator of hair follicle stem cell (HFSC) fate
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism amine
    signaling
    being a rate-limiting enzyme in the catabolic pathway of polyamine metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SLC3A2
  • SAT1 has been reported to exert other effects in cells by its interaction with other cellular proteins, but EIF5A is the first target protein specifically acetylated by SAT1
  • depletion of the polyamines spermidine and spermine by overexpression of SAT1 leads to mitochondria-mediated apoptosis in mammalian cells
  • TP53 can enhance ferroptosis by inhibiting the expression of SLC7A11 or by enhancing that of SAT1 and GLS2
    • cell & other
    REGULATION
    induced by ischemia
    AMPK signaling
    inhibited by K-RAS (negatively regulates SLC3A2 and SAT1 expression)
    ASSOCIATED DISORDERS
    corresponding disease(s) KFSD , DUPXP
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    may potentially be a therapeutic target to sensitize GBM to cancer therapies
    ANIMAL & CELL MODELS