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FLASH GENE
Symbol PHKA2 contributors: mct - updated : 08-09-2011
HGNC name phosphorylase kinase, alpha 2 (liver)
HGNC id 8926
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node   highly
Nervousnerve   highly
Reproductivemale systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure polymer of 16 chains, four each of alpha, beta, gamma, and delta
mono polymer polymer
HOMOLOGY
interspecies homolog to murine Phka2
Homologene
FAMILY
  • phosphorylase b kinase regulatory chain family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • catalyzing the phosphorylation of serine in certain substrates
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycan biosynthesis
    a component
  • polymer of 16 chains, four each of alpha, beta, gamma, and delta ; alpha and beta are regulatory chains, gamma is
    • the catalytic chain, and delta is calmodulin
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulation by phosphorylation of various serine residues and by calcium
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD6B , GSD9A
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS