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FLASH GENE

Symbol

PHKA2

contributors: mct - updated : 08-09-2011

HGNC name	phosphorylase kinase, alpha 2 (liver)
HGNC id	8926

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	92.07 kb     33 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_000292 33 - 5325 NP_000283 138 1235 - 1999 10330341

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Lymphoid/Immune lymph node       highly Nervous nerve       highly Reproductive male system testis     highly

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

secondary structure

polymer of 16 chains, four each of alpha, beta, gamma, and delta

mono polymer

polymer

HOMOLOGY

interspecies

homolog to murine Phka2

Homologene

FAMILY

phosphorylase b kinase regulatory chain family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

catalyzing the phosphorylation of serine in certain substrates

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

glycan biosynthesis

a component	polymer of 16 chains, four each of alpha, beta, gamma, and delta ; alpha and beta are regulatory chains, gamma is
	the catalytic chain, and delta is calmodulin

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulation by phosphorylation of various serine residues and by calcium

ASSOCIATED DISORDERS

corresponding disease(s)

GSD6B , GSD9A

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS