protein
| interacting with CITED2 (CITED2 acts in the gonad with WT1 and NR5A1 to increase the expression of SRY levels to attain a critical threshold to efficiently initiate testis development) (Buaas 2009) |
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interactions with other co-regulators, particularly ZNF208, are essential for its functions as either a transactivator or repressor of its target genes (Peng 2009) |
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recruits the KRAB-TRIM28 complex as a chromatin modulator (Peng 2009) |
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binds directly to a testis-specific enhancer of SOX9 (TES) and activates SOX9 expression in co-operation with steroidogenic factor 1 (SF1) |
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TFCP2 is an essential transcription factor for SRY expression regulation |
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RPS7 (ribosomal protein S7) and RPL13a (ribosomal protein L13a) interact with the HMG (high-mobility group) box domain of SRY |
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SRY and NR5A1 co-operate to activate the human SOX9 homologous TES, a process dependent on phosphorylated NR5A1 |
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SRY acts directly on the TCF21 promoter to in part initiate a cascade of events associated with Sertoli cell differentiation and embryonic testis development |
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WDR5, which encodes a WD-40 repeat protein, is a direct target of SRY (interaction of WDR5 with SRY resulted in activation of SOX9 while repressing the expression of CTNNB1) |
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HSPA8 plays a key role in CALM1-dependent nuclear import of SRY |
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SRY upregulation after dopamine cell injury is initially a protective response in males, but diminishes with gradual loss in dopamine cells, and dysregulation of SRY may potentially contribute the susceptibility of males to Parkinson disease |
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transcriptional factor SRY specifically binds to different sites in the promoter sequence and has the ability to control CATSPER1 gene transcription |