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FLASH GENE

Symbol

XIST

contributors: mct - updated : 07-05-2016

HGNC name	X (inactive)-specific transcript
HGNC id	12810

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       promoter mutated in skewed X inactivation and the choice of X chromosome inactivation reflects stabilization of a higher order chromatin conformation impinging on the CTCF-XIST promoter complex tumoral     --other   aberrantly demethylated in testicular germ cell tumor and in male-derived plasma tumoral     --over   by demethylation in aggressive prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS