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FLASH GENE
Symbol TNNI3 contributors: SGE/npt - updated : 27-12-2016
HGNC name troponin I type 3 (cardiac)
HGNC id 11947
ASSOCIATED DISORDERS
corresponding disease(s) CMH7 , CMD1FF
related resource FHCMutationDatabase
Susceptibility
Variant & Polymorphism
Candidate gene
  • two novel missense mutations (Lys36Gln, Asn185Lys) causing autosomal dominant dilated cardiomyopathy (Carballo 2009)
  • combination of elevated CRP and TNNI3 increase the risk of adverse cardiac events (Huang 2009)
  • elevated TNNI3 levels are significantly associated with short- and long-term mortality in ESRD patients with sepsis (Kang 2009)
  • Marker
  • NPPB and TNNI3 are useful markers for identifying patients at risk for clinical deteriorations, and combined measurements of these biomarkers further improves the prognostic value of increased cardiovascular events in hypertrophic cardiomyopathy (HCM)
  • Therapy target
    SystemTypeDisorderPubmed
    cardiovascularaquired 
    may be a useful tool in identifying patients with heart failure who are at increased risk for progressive ventricular dysfunction and death
    ANIMAL & CELL MODELS