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FLASH GENE
Symbol LAMP2 contributors: mct/npt/pgu - updated : 07-07-2021
HGNC name lysosomal-associated membrane protein 2
HGNC id 6501
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular N glycosylation sites
  • a transmembrane segment
  • a short cytoplasmic tail
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • LAMP family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    text
  • type 1 membrane protein
  • shuttles between lysosomes and the cell membrane
    • basic FUNCTION
  • playing a role in protection of the lysosomal membrane from autodigestion and maintenance of the acidic environment of the lysosome
  • has established roles in adhesion and cellular homeostasis, including autophagocytosis and antigen presentation
  • LAMP1 and LAMP2 are delivered to phagosomes during the maturation process
  • participates in chaperone-mediated autophagy, lysosome biogenesis, lysosome-autophagosome fusion, and lysosome locomotion along microtubule tracts toward phagosomes
  • may be involved the pathogenesis of accessory AV connections
  • may participate in chaperone-mediated autophagy.Autophagy regulates T-lymphocyte homeostasis by promoting both survival and proliferation
  • WDFY1 and LAMP2 can likely influence MTORC1 activity and regulate autophagy
  • LAMP1 and LAMP2 have distinct functions, and the presence of both proteins together is required for the essential regulation of autophagy to avoid embryonic lethality
  • plays a critical role in lysosomal biogenesis and maturation of autophagosomes/phagosomes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of membrane
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LAMP2 attenuates EMT by suppressing SNAI1 expression in hepatocellular carcinoma (HCC)
  • LGALS9 is enriched in lysosomes and predominantly binds to lysosome-associated membrane protein 2 (LAMP2) in a Asn(N)-glycan dependent manner
    • cell & other
  • lysosomal associated
    • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD2B
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in rimmed vacuoles
    constitutional     --low  
    may contribute to the formation of basal laminar deposits (BLamDs) in age-related macular degeneration (AMD)
    constitutional     --over  
    can improve autophagic flux blockade probably by promoting the trafficking of cathepsins and consequently conferring cardiomyocyte resistance against lysosomal cell death (LCD) that is induced by ischemic injury
    Susceptibility
  • to pauci-immune focal necrotizing glomerulonephritis
  • to accessory atrioventricular connections
    • Variant & Polymorphism other infection with fimbriated bacteria induces autoantibodies to LAMP2 through molecular mimicry and these antibodies bind microvascular endothelium and cause injury
    Candidate gene for MEAX
    Marker
  • High expression of LAMP2 predicts poor prognosis in patients with esophageal squamous cell carcinoma (ESCC)
    • Therapy target
    ANIMAL & CELL MODELS
  • deletion of the Lamp2 gene in mice resulted in age-dependent autofluorescence abnormalities of the fundus, thickening of Bruch's membrane 7)