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FLASH GENE

Symbol

SYP

contributors: mct - updated : 13-11-2014

HGNC name	synaptophysin
HGNC id	11506

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MRX96

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in mental retardation

Susceptibility

to attention deficit hyperactivity disorder

Variant & Polymorphism SNP	associated to attention deficit hyperactivity disorder
	interaction of MAOA and SYP may be involved in the genetic mechanism of ADHD-I subtype

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	mice lacking Syp, a modulator of neurotransmitter release, are defective in delaying clock phase
	from mice 9 months old on, a progressive decrease of the presence of SYP was found under Inner hair cells and outer (OHCs) hair cells rows starting at the basal coil and reaching the apical coil in the oldest mice